Webinar

Simultaneous measurement of cellular concentration and antibody affinity of HER2 oncoprotein by combining Microfluidic Diffusional Sizing and native nanodiscs

Published on October 6th, 2022

This webinar, the second part of a 2-part mini-webinar series, was presented by Sandro Keller Full Professor and Head of the Biophysics Division at the Institute of Molecular Biosciences (IMB) at the University of Graz, Austria

In the webinar Sandro:

  • Provided a brief recap of microfuidic diffusional sizing (MDS)
  • Gave an introduction to native nanodiscs
  • Reviewed 3 x case studies:
    • Protein–protein interactions: HER2/trastuzumab binding
    • Protein–lipid interactions: α-synuclein binding to lipids
    • Particle sizing: native membrane-protein libraries

You can view Part#1 of our webinar series here: Membrane-protein characterization by MDS – an introduction to applications and workflows

Sandro Keller is Full Professor and Head of the Biophysics Division at the Institute of Molecular Biosciences (IMB) at the University of Graz, Austria Sandro Keller is Full Professor and Head of the Biophysics Division at the Institute of Molecular Biosciences (IMB) at the University of Graz, Austria

University of Graz, Austria

Sandro Keller is Full Professor and Head of the Biophysics Division at the Institute of Molecular Biosciences (IMB) at the University of Graz, Austria. He has a PhD in Physical Chemistry from Martin Luther University, Halle, Germany, and more than 15 years of research experience in the field of experimental membrane biophysics.

The research focus of Sandro’s group is on understanding biomolecular interactions in a membrane environment. To this end, the group develops both new membrane-mimetic systems and novel biophysical methods that help decipher the complex interactions between proteins embedded in a lipid-bilayer membrane.

Sandro has published more than 100 peer-reviewed scientific publications and has been invited more than 100 times to give oral presentations at international conferences and workshops. He has received several awards, including the prestigious Stig Sunner Memorial Award from the North American Calorimetry Conference (CALCON), and serves on the Editorial Boards of several scientific journals.