A Fluidic Sciences brand
Cell selection, sorted.
High-throughput single-cell screening powered by picodroplet microfluidic technology – for antibody discovery, cell line development and monoclonality verification.
Fluidity One-M
from Fluidic Sciences
Move faster – from binding to findings.
Binding affinity, concentration, stoichiometry and size in solution – a full binding curve and KD in a simple 25-minute workflow.
Seamlessly traverse cellular function
and molecular binding
As the home of Sphere Bio and Fluidity One‑M, we deliver an end‑to‑end portfolio for complex biology. Move seamlessly from multiplex single‑cell screening to in‑solution biophysics – reducing assumptions and accelerating confident decisions.
Meet Fluidity One-M
Our toolbox to fast-track protein interaction analysis
Measure in solution
Direct measurement in solution without purification and immobilization.
Start simple
Just mix and measure, with machine learning guided assays
Break the constraints
Works for any targets and backgrounds, such as serum, plasma and cell lysate
Work faster
Get a full binding curve and KD with a simple workflow in 25 minutes
Avoid biases
With single-use consumables. No cross-contamination
Complete the picture
Binding affinity, concentration, stoichiometry and size, all at once
Driven by cutting-edge technologies
Rapid and easy determination of hydrodynamic sizes and interactions of biomolecules in solution
Get to know Microfluidic Diffusional Sizing (MDS), the technology that drives our products. MDS gives one simple and direct measurement – protein molecular size. When binding occurs, changes in protein size are monitored and used to determine binding affinity and calibration-free concentration or binding stoichiometry.
Microfluidic Diffusional Sizing
Picodroplet Microfluidic Technology
The core of our Cyto-Mine® platforms
Each picodroplet is used to encapsulate a cell. The chemistry of the emulsions is carefully designed to give long-term stable, biocompatible droplets with minimal leakage of molecules from the droplet, right down to small molecules such as metabolites. This provides an ultra-miniaturized test tube, containing media, reagents, and cells, that allows large-scale experiments at the single cell level.
Win the race to insights
Accelerate protein interaction analysis across a wide range of research areas
Membrane protein characterization & quantification
Serum antibody concentration
& affinity
Monoclonal therapeutic antibody characterization
Affinity & stoichiometry of amyloid species
Quality control of reagents & protein activity
Organ transplant recipient immunoprofiling
What our users say
“MDS allows simultaneously determining both concentration and affinity of donor-specific antibodies under native conditions, directly in clinical samples, which is highly valuable.
MDS concentration/affinity tests have the potential to replace expensive antibody titre-determinations.
We particularly appreciate the high degree of standardisation of this approach, making it well suited for use in clinical laboratories.”
Dr Gideon Hoenger University Hospital Basel “We initially developed the MDS technology in our lab and have now switched to using the Fluidity One M instrument for all of our MDS and protein interaction work because it’s very robust and convenient.”
Prof. Tuomas Knowles University of Cambridge “MDS allowed us to obtain unique information that helped us elucidate, for the first time, the way antibody therapeutics bind to different forms of their targets.”
Prof. Sara Linse Lund University