Webinar

Using MDS to observe protein oligomerization

In this webinar we explore protein oligomerization, and look at two case studies where microfluidic diffusional sizing (MDS) was used to observe changing oligomeric states.

Watch on demand here

You can also learn more about oligomerization and MDS with the resources below.

  • Publications and resources

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    • Brochure

      Fluidity One brochure

      The Fluidity One brochure gives an overview of the capabilities, applications and full technical specifications.

    • Application note

      Oligomerization of Interleukin-2

      A commercially available human interleukin-2 is assessed by microfluidic diffusional sizing on the Fluidity One across a dilution series. The hydrodynamic radius is observed to increase with increasing concentration, in a way which suggests a monomer-trimer equilibrium with positive cooperativity is established.

    • Application note

      Detecting insulin oligomerization using microfluidic diffusional sizing

      Insulin monomers self-assemble into hexamers, which is known to affect its level of uptake in the human body. Here we show that Microfluidic Diffusional Sizing (MDS) can be used to detect these changes.

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