Webinar

Using MDS to observe protein oligomerization

In this webinar we explore protein oligomerization, and look at two case studies where microfluidic diffusional sizing (MDS) was used to observe changing oligomeric states.

Watch on demand here

You can also learn more about oligomerization and MDS with the resources below.

  • Publications and resources

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    • Blog24 May 2019

      5 great reads: Protein-protein interactions and disease

      Here are five of our favorite recent publications, highlighting both the role of protein-protein interactions in disease and how the characterization of these interactions may allow the development of new therapeutic strategies.

    • Brochure24 August 2018

      Fluidity One brochure

      The Fluidity One brochure gives an overview of the capabilities, applications and full technical specifications.

    • Application note22 August 2018

      Oligomerization of Interleukin-2

      A commercially available human interleukin-2 is assessed by microfluidic diffusional sizing on the Fluidity One across a dilution series. The hydrodynamic radius is observed to increase with increasing concentration, in a way which suggests a monomer-trimer equilibrium with positive cooperativity is established.

    • Application note10 May 2018

      Detecting insulin oligomerization using microfluidic diffusional sizing

      Insulin monomers self-assemble into hexamers, which is known to affect its level of uptake in the human body. Here we show that Microfluidic Diffusional Sizing (MDS) can be used to detect these changes.

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