Documentation

Fluidity One and One-W comparator

This overview document quickly outlines the differences between our Fluidity One and Fluidity One-W instruments, in terms of applications and technical specifications.

Download the pdf here.

Find more detail on both instruments in our product pages for the One or One-W, or if you have a specific question contact our team here.

  • Publications and resources

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    • Application note02 April 2019

      Determination of lipid protein binding stoichiometry using Microfluidic Diffusional Sizing

      Here we assess the stoichiometry of α-synuclein binding to lipid vesicles by microfluidic diffusional sizing (MDS) on the Fluidity One and Circular Dichroism (CD). We find that the results obtained are consistent between the two techniques, but that MDS presents advantages in both speed and simplicity.

    • Application note01 April 2019

      Determination of KD of aptamer protein interactions by microfluidic diffusional sizing

      Here the Fluidity One-W is used to experimentally determine the KD of two protein aptamer interactions, with results in good agreement with literature values. Importantly the technique required no calibration, complex setup or specialist sample preparation. Furthermore, the interaction is assessed without immobilising or altering either molecule beyond the addition of a standard fluorescent label.

    • Infographic07 March 2019

      The KD cheat sheet

      This printable "cheat sheet" gives an overview of what KD, the dissociation constant, means, how to calculate it, and how to experimentally measure it.

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