Video20 August 2019Application note video summaries
On this page we collect short video summaries of our application notes
Video13 August 2019Conference Poster Presentations 2019
Throughout 2019 we will be attending conferences all over the world and seeking out research topics and poster presetations we really think are worth taking a look at. Check back here regularly for videos of poster presentations that present cutting edge science from around the globe.
Blog11 July 2019Understanding why GPCRs are difficult to study
In this blog post we delve into the reasons behind why elucidating GPCR structures are so important as well as why they are hard to study.
Application note04 April 2019Rapid quality control of commercially available antibodies by MDS for acceptance testing
Size presents a simple metric to assess quality as an indicator of aggregation and degradation. Here MDS on the Fluidity One and SEC analysis are both used to check 6 commercially available antibodies. Both techniques sucessfully identify problem samples, but MDS does so with 80% less time and 90% less sample.
Blog08 March 2019Protein analysis techniques - a history and timeline
Proteins were discovered in the late 18th century, but analytical methods to observe them were not developed until more than 100 years later. This timeline shows when different techniques were developed.
Blog04 February 2019Protein aggregation - why it matters, and how to study it
A growing field of research is dedicated to protein aggregation, which can be useful, functional or unwanted. This article explores some of the reasons why proteins aggregate, and details the techniques available to study it.
Application note11 December 2018Quantitation of low Tryptophan and Tyrosine peptides using the Fluidity One
UV absorbance is commonly used as a fast method for protein and peptide quantitation, however samples must contain tryptophan (Trp) or tyrosine (Tyr) residues to be detected. Here we demonstrate the ability of the Fluidity One to assess the concentration of a range of samples which have low or no Trp and Tyr content.
Blog21 June 2018How does Microfluidic Diffusional Sizing (MDS) compare to Dynamic Light Scattering (DLS) for protein size tests?
Measuring the size of proteins provides insights into folding and conformations, aggregation and oligomerization. We compare and contrast the benefits and limitations of two popular techniques - DLS Dynamic Light Scattering, and MDS Microfluidic Diffusional Sizing.
Application note14 June 2018A comparison of Microfluidic Diffusional Sizing with Dynamic Light Scattering and Taylor Dispersion Analysis
The established technologies of Dynamic Light Scattering (DLS) and Taylor Dispersion Analysis (TDA) are compared to Microfluidic Diffusional Sizing (MDS) for sizing proteins of varying molecular weights and at varying concentrations. We show that MDS offers comparable sizing of proteins over a range of sizes, and can provide consistent sizing to lower concentrations than the other techniques.
Blog30 May 2018How does the Fluidity One compare to UV-Vis spectrophotometers in testing the concentration of proteins?
UV-vis absorbance testing is a popular method for rapid testing of protein concentration with only a small sample volume needed. Here we compare this method to Microfluidic Diffusional Sizing (MDS), as used on the Fluidity One, to see how the workflow, accuracy, test method, range and limitations compare.
Blog17 May 2018Protein size - how do I measure it, and why is it important?
An overview of why protein size matters, and what structural and functional information protein size can reveal. To understand proteins and their function, we have to understand the way they fold, aggregate and interact. Conformation is key to protein function and can be revealed by measuring size.
Different methods for measuring protein size are summarised, and comparison is made, considering the method, range, cost and limitations of each technology.
Blog23 April 2018What analytical laboratory methods are available for protein quantification? How do they compare?
Quantification is an essential part of protein analysis and quality control. Here we look at the various approaches for protein quantification, their advantages, and their limitations.