Blog06 September 2019The role of chaperones
In this article, we look at what chaperones are, what role they play in the body and how MDS is being utilized to study them.
Blog23 August 2019Looking at the numbers: Why protein stoichiometry matters
Accurate determination of stoichiometry for a protein complex is critical to our understanding how the complex will react to other proteins or small molecules. Here we look at how stoichiometry not only effects important viral protein-antibody interactions but also disease pathology.
Video13 August 2019Conference Poster Presentations 2019
Throughout 2019 we will be attending conferences all over the world and seeking out research topics and poster presetations we really think are worth taking a look at. Check back here regularly for videos of poster presentations that present cutting edge science from around the globe.
Video12 August 2019Measuring IL2 Stability in different buffers using Microfluidic Diffusional Sizing (MDS)
In this video we look at how a commercially available human interleukin-2 is assessed by microfluidic diffusional sizing on the Fluidity One across a dilution series. The hydrodynamic radius is observed to increase with increasing concentration, in a way which suggests a monomer-trimer equilibrium with positive cooperativity is established.
Webinar22 March 2019Using MDS to observe protein oligomerization
In this webinar we explore protein oligomerization, and look at two case studies where microfluidic diffusional sizing (MDS) was used to observe changing oligomeric states.
Publication15 June 2018Cooperative Assembly of Hsp70 Subdomain Clusters
Wright et al use Microfluidic Diffusional Sizing to probe the oligomerisation of the SBD641 substrate of human Hsp70. The Fluidity One was employed to verify if the fluorescent label used had an affect on measured hydrodynamic radius during the tests.