Publication25 July 2019Microfluidic diffusional sizing (MDS) in the literature
Document referencing all the publications where microfluidic diffusional sizing (MDS) has been used.
Publication24 July 2019Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials.
Macikova et al use Microfluidic Diffusional Sizing (MDS) along with other techniques to understand the role phosphatidylinositol-4,5-bisphosphate (PIP2) has in the regulation of transient receptor potential ankyrin 1 (TRPA1) channel. The Fluidity One was used to create binding curves of the interactions between two specific peptides (L992-N1008 and T1003-P1034) and model lipid membranes in the presence of PIP2.
Publication04 June 2019Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates
In this paper MDS was used to identify two molecular chaperones which suppress secondary nucleation processes and inhibit the elongation of Aβ fibrils seen in Alzheimer's disease.
Webinar22 March 2019Using MDS to observe protein oligomerization
In this webinar we explore protein oligomerization, and look at two case studies where microfluidic diffusional sizing (MDS) was used to observe changing oligomeric states.
Publication06 March 2019α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
This paper probes the interactions of α-synuclein with lipid particles using the Fluidity One and various other methods, to investigate the link between these interactions and α-synuclein aggregation.
Documentation11 February 2019Fluidity One quick start guide
This handy quick start guide will have you running tests and interpreting results on the Fluidity One as soon as possible.
Documentation02 January 2019Fluidity One User Manual
The Fluidity One user manual with full safety and operation information.
Blog14 September 2018Basel Life and Miptec 2018 - poster and presentation download
The Miptec exhibition at Basel Life 2018 marked the official launch of our Fluidity One instrument. Download a copy of our poster and presentation from the event here.
Publication15 June 2018Cooperative Assembly of Hsp70 Subdomain Clusters
Wright et al use Microfluidic Diffusional Sizing to probe the oligomerisation of the SBD641 substrate of human Hsp70. The Fluidity One was employed to verify if the fluorescent label used had an affect on measured hydrodynamic radius during the tests.