Can the Fluidity One spot aggregates in a mixture with monomers?

Aggregates would result in an increase in the average hydrodynamic radius (Rh) of the proteins in solution. Provided you have prior knowledge of the monomeric protein size, then it should be possible to detect aggregates in a mixture with monomers.

For solutions where you are searching for trace amounts of aggregates, DLS may be more appropriate due to its bias towards large species detection.

In instances where you want to monitor aggregate formation over time, or are interested in early stage aggregates, the average Rh given by the Fluidity One will provide better insights.

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