Publications, application notes and more

Infographic07 March 2019

This printable "cheat sheet" gives an overview of what KD, the dissociation constant, means, how to calculate it, and how to experimentally measure it.

Publication06 March 2019

This paper probes the interactions of α-synuclein with lipid particles using the Fluidity One and various other methods, to investigate the link between these interactions and α-synuclein aggregation.

Infographic18 February 2019

This infographic captures the results of our recent survey, asking researchers in protein science what research areas are important, and how they conduct their analyses.

Documentation11 February 2019

This handy quick start guide will have you running tests and interpreting results on the Fluidity One as soon as possible.

Blog06 February 2019

There are many proteins which interact with lipids in vivo, in complex relationships that have crucial impacts on organism health. These are often thought of as disease causing, but can also play roles in normal biochemical functions. Here are some examples of protein-lipid interactions from around the human body, which play a part in healthy activity in cells.

Blog04 February 2019

A growing field of research is dedicated to protein aggregation, which can be useful, functional or unwanted. This article explores some of the reasons why proteins aggregate, and details the techniques available to study it.

Blog04 February 2019

Protein X is a key suspect in causing disease Y. So how do you study protein X?

Here we look at biophysics from a biologist's point of view; asking why is biophysics important? What can biophysics contribute to biology? And what biophysics techniques should biologists know about, and use?

Documentation02 January 2019

The Fluidity One user manual with full safety and operation information.

Blog29 November 2018

As the $31m investment round in Fluidic Analytics is announced, Vishal Gulati of Draper Esprit reflects on how he first met the founders, why proteins matter and how our technology is set to change protein science.

Documentation24 October 2018

Blog14 September 2018

The Miptec exhibition at Basel Life 2018 marked the official launch of our Fluidity One instrument. Download a copy of our poster and presentation from the event here.

Blog17 July 2018

An array of characteristics must be investigated in new biopharmaceuticals to evaluate their safety, efficacy and behaviour under changing conditions. Here we look at what specific attributes should be measured and why.

Blog17 July 2018

Principal Software Engineer, Mauricio Varea, talks about his career path to date, working in large and small companies and what a typical day looks like for him at Fluidic Analytics.

Blog18 June 2018

An interview with Dr Maren Butz, senior scientist at Fluidic Analytics. We find out what an average day looks like for her, how work in academia compares to industry, and how her work contributes to developing our instruments.

Publication15 June 2018

Wright et al use Microfluidic Diffusional Sizing to probe the oligomerisation of the SBD641 substrate of human Hsp70. The Fluidity One was employed to verify if the fluorescent label used had an affect on measured hydrodynamic radius during the tests.

Publication02 February 2018

Hongze Gang in the Tuomas Knowles lab demonstrates the use of microfluidic diffusional sizing for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.

Publication01 December 2017

In this paper, Herling et al demonstrate a microfluidic platform for the detection of protein-ligand interactions with an assay time on the second timescale and without the requirement for immobilization or the presence of a highly viscous matrix.

Publication01 December 2017

Zhang et al again demonstrate the utility of Microfluidic Diffusional Sizing to monitor Nanobody binding to ɑ-synuclein, but this time also use MDS to monitor ɑ-synuclein fibril formation.

Publication01 December 2017

Arosio et al demonstrate the utility of a diffusion viscometer, showing that by including tracer particles and tracking mass transport, the viscosity of complex solutions can be determined using only low quantities of sample material, with a short analysis time and can be integrated into other microfluidic elements on a chip.

Publication01 December 2017

In this paper, Yates et al show that the technology behind Fluidic Analytics instruments - microfludic diffusional sizing - can be used to accurately size a range of proteins.