Resources

Publications, application notes and more

  • Publication25 July 2019

    Microfluidic diffusional sizing (MDS) in the literature

    Document referencing all the publications where microfluidic diffusional sizing (MDS) has been used.

  • Video24 July 2019

    Lucie Machikova - EBSA IUPAP 2019 Poster video

    Lucie Machikova talking through her poster detailing the work carried out in her publication "Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials".

  • Publication24 July 2019

    Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials.

    Macikova et al use Microfluidic Diffusional Sizing (MDS) along with other techniques to understand the role phosphatidylinositol-4,5-bisphosphate (PIP2) has in the regulation of transient receptor potential ankyrin 1 (TRPA1) channel. The Fluidity One was used to create binding curves of the interactions between two specific peptides (L992-N1008 and T1003-P1034) and model lipid membranes in the presence of PIP2.

  • Blog11 July 2019

    Understanding why GPCRs are difficult to study

    In this blog post we delve into the reasons behind why elucidating GPCR structures are so important as well as why they are hard to study.

  • Infographic11 July 2019

    Researching therapies for Alzheimer’s Disease

    In this infographic, we break down all the failures of potential therapies that were tested to treat Alzheimer's Disease. This includes a cost and percentage breakdown of the clinical phases in which these therapies failed in as well as statistics for world-wide Alzherimer's Disease epidemiology.

  • Blog04 July 2019

    The Protein Society Symposium 2019 roundup

    In this blog post we showcase videos of authors taking us through their poster presentations and highlight key papers from the talks from our favourite seven topics.

  • Blog03 July 2019

    Affinity vs Avidity- What's the difference?

    In this blog post we will be delving into the differences between affinity and avidity

  • Brochure27 June 2019

    Fluidity One-W Brochure

    This brochure gives an overview of the capabilities, applications and full technical specifications of the Fluidity One-W

  • Publication04 June 2019

    Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

    In this paper MDS was used to identify two molecular chaperones which suppress secondary nucleation processes and inhibit the elongation of Aβ fibrils seen in Alzheimer's disease.

  • Blog24 May 2019

    5 great reads: Protein-protein interactions and disease

    Here are five of our favorite recent publications, highlighting both the role of protein-protein interactions in disease and how the characterization of these interactions may allow the development of new therapeutic strategies.

  • Publication18 April 2019

    PEGS Boston 2019 poster

    Download a copy of our poster as shown at PEGS 2019 here, titled; Microfluidic Diffusional Sizing (MDS) for protein characterization – latest results and next steps.

  • Application note03 April 2019

    Determination of KD of aptamer protein interactions by microfluidic diffusional sizing

    Here the Fluidity One-W is used to experimentally determine the KD of two protein aptamer interactions, with results in good agreement with literature values. Importantly the technique required no calibration, complex setup or specialist sample preparation. Furthermore, the interaction is assessed without immobilising or altering either molecule beyond the addition of a standard fluorescent label.

  • Blog02 April 2019

    When protein-lipid interactions matter

    This blog explores some examples from the literature where the interactions of proteins and lipids have made a big impact on the overall research.

  • Webinar22 March 2019

    Using MDS to observe protein oligomerization

    In this webinar we explore protein oligomerization, and look at two case studies where microfluidic diffusional sizing (MDS) was used to observe changing oligomeric states.

  • Blog18 March 2019

    5 exciting papers on membrane proteins

    This list gives a summary and link to 5 excellent papers which highlight some of the most recent and exciting work taking place in the field of membrane proteins.

  • Blog08 March 2019

    Protein analysis techniques - a history and timeline

    Proteins were discovered in the late 18th century, but analytical methods to observe them were not developed until more than 100 years later. This timeline shows when different techniques were developed.

  • Infographic07 March 2019

    The KD cheat sheet

    This printable "cheat sheet" gives an overview of what KD, the dissociation constant, means, how to calculate it, and how to experimentally measure it.

  • Publication06 March 2019

    α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation

    This paper probes the interactions of α-synuclein with lipid particles using the Fluidity One and various other methods, to investigate the link between these interactions and α-synuclein aggregation.

  • Infographic18 February 2019

    Views from the lab 2019

    This infographic captures the results of our recent survey, asking researchers in protein science what research areas are important, and how they conduct their analyses.

  • Documentation11 February 2019

    Fluidity One quick start guide

    This handy quick start guide will have you running tests and interpreting results on the Fluidity One as soon as possible.