Publications, application notes and more

  • Blog

    Protein DLS result not as expected? Try these troubleshooting tips

    If your DLS result for a protein sample is not what you expected, it could be down to one of these common reasons. Use this list to troubleshoot your DLS protein results fast.

  • Documentation

    Fluidity One quick start guide

    This handy quick start guide will have you running tests and interpreting results on the Fluidity One as soon as possible.

  • Documentation

    Fluidity One and One-W comparator

    This overview document quickly outlines the differences between our Fluidity One and Fluidity One-W instruments.

  • Blog

    Born Slippy; Protein-Lipid interactions around the human body

    There are many proteins which interact with lipids in vivo, in complex relationships that have crucial impacts on organism health. These are often thought of as disease causing, but can also play roles in normal biochemical functions. Here are some examples of protein-lipid interactions from around the human body, which play a part in healthy activity in cells.

  • Blog

    Protein aggregation - why it matters, and how to study it

    A growing field of research is dedicated to protein aggregation, which can be useful, functional or unwanted. This article explores some of the reasons why proteins aggregate, and details the techniques available to study it.

  • Blog

    Biophysics for Biologists

    Protein X is a key suspect in causing disease Y. So how do you study protein X? Here we look at biophysics from a biologist's point of view; asking why is biophysics important? What can biophysics contribute to biology? And what biophysics techniques should biologists know about, and use?

  • Documentation

    Fluidity One User Manual

    The Fluidity One user manual with full safety and operation information.

  • Blog

    The role of analytics in the discovery and development of biopharmaceuticals

    As the biopharmaceuticals market continues to grow, how do laboratory analysis methods support discovery and development? And what should be considered when selecting an analysis method?

  • Application note

    Quantitation of low Tryptophan and Tyrosine peptides using the Fluidity One

    UV absorbance is commonly used as a fast method for protein and peptide quantitation, however samples must contain tryptophan (Trp) or tyrosine (Tyr) residues to be detected. Here we demonstrate the ability of the Fluidity One to assess the concentration of a range of samples which have low or no Trp and Tyr content.

  • Blog

    Social Network. But For Proteins

    As the $31m investment round in Fluidic Analytics is announced, Vishal Gulati of Draper Esprit reflects on how he first met the founders, why proteins matter and how our technology is set to change protein science.

  • Application note

    Protein Size as an Indication of Structure

    Molecular weight (Mw) is a commonly used, and for many scientists a readily understood, parameter to describe the size of a protein or complex. Here we show how hydrodynamic radius (Rh) can be used in combination with Mw to provide insights into the shape and structure of proteins and illustrate how Mw alone may not always provide a complete picture.

  • Documentation

    Fluidity One Chip Flow factsheet

    This factsheet shows how the microfluidic chips used with the Fluidity One work, through diagrams and a short description.

  • Video

    Introducing The Fluidity One - video

    This short video introduces the Fluidity One instrument, how it works, what Microfluidic Diffusional Sizing MDS is, and why native state protein analysis is so vital.

  • Blog

    Basel Life and Miptec 2018 - poster and presentation download

    The Miptec exhibition at Basel Life 2018 marked the official launch of our Fluidity One instrument. Download a copy of our poster and presentation from the event here.

  • Brochure

    Fluidity One brochure

    The Fluidity One brochure gives an overview of the capabilities, applications and full technical specifications.

  • Application note

    Oligomerization of Interleukin-2

    A commercially available human interleukin-2 is assessed by microfluidic diffusional sizing on the Fluidity One across a dilution series. The hydrodynamic radius is observed to increase with increasing concentration, in a way which suggests a monomer-trimer equilibrium with positive cooperativity is established.

  • Application note

    Interleukin-2 stability in changing buffer and temperature conditions

    The stability of interleukin-2 in different buffers and storage temperatures is evaluated using the Fluidity One. We find that IL-2 forms aggregates within 24 hours in some buffers, and that the Fluidity One provides a simple means to evaluate the stability of proteins across different conditions.

  • Documentation

    Removing primary amine containing additives from protein samples prior to testing on Fluidity One

    A laboratory protocol for removing additives that contain primary amines before testing on the Fluidity One.

  • Blog

    What biophysical attributes of biopharmaceuticals are measured, and why?

    An array of characteristics must be investigated in new biopharmaceuticals to evaluate their safety, efficacy and behaviour under changing conditions. Here we look at what specific attributes should be measured and why.