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Blog
Understanding why GPCRs are difficult to studyIn this blog post we delve into the reasons behind why elucidating GPCR structures are so important as well as why they are hard to study.
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Infographic
Researching therapies for Alzheimer’s DiseaseIn this infographic, we break down all the failures of potential therapies that were tested to treat Alzheimer's Disease. This includes a cost and percentage breakdown of the clinical phases in which these therapies failed in as well as statistics for world-wide Alzherimer's Disease epidemiology.
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Blog
The Protein Society Symposium 2019 roundupIn this blog post we showcase videos of authors taking us through their poster presentations and highlight key papers from the talks from our favourite seven topics.
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Blog
Affinity vs Avidity- What's the difference?In this blog post we will be delving into the differences between affinity and avidity
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Brochure
Fluidity One-W BrochureThis brochure gives an overview of the capabilities, applications and full technical specifications of the Fluidity One-W
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Publication
Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregatesIn this paper MDS was used to identify two molecular chaperones which suppress secondary nucleation processes and inhibit the elongation of Aβ fibrils seen in Alzheimer's disease.
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Blog
5 great reads: Protein-protein interactions and diseaseHere are five of our favorite recent publications, highlighting both the role of protein-protein interactions in disease and how the characterization of these interactions may allow the development of new therapeutic strategies.
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Publication
PEGS Boston 2019 posterDownload a copy of our poster as shown at PEGS 2019 here, titled; Microfluidic Diffusional Sizing (MDS) for protein characterization – latest results and next steps.
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Application note
Rapid quality control of commercially available antibodies by MDS for acceptance testingSize presents a simple metric to assess quality as an indicator of aggregation and degradation. Here MDS on the Fluidity One and SEC analysis are both used to check 6 commercially available antibodies. Both techniques sucessfully identify problem samples, but MDS does so with 80% less time and 90% less sample.
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Blog
When protein-lipid interactions matterThis blog explores some examples from the literature where the interactions of proteins and lipids have made a big impact on the overall research.
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Application note
Determination of lipid protein binding stoichiometry using Microfluidic Diffusional SizingHere we assess the stoichiometry of α-synuclein binding to lipid vesicles by microfluidic diffusional sizing (MDS) on the Fluidity One and Circular Dichroism (CD). We find that the results obtained are consistent between the two techniques, but that MDS presents advantages in both speed and simplicity.
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Application note
Determination of KD of aptamer protein interactions by microfluidic diffusional sizingHere the Fluidity One-W is used to experimentally determine the KD of two protein aptamer interactions, with results in good agreement with literature values. Importantly the technique required no calibration, complex setup or specialist sample preparation. Furthermore, the interaction is assessed without immobilising or altering either molecule beyond the addition of a standard fluorescent label.
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Infographic
Which protein sizing technique is right for me?This infographic lays out the key considerations you should think of when choosing a protein sizing technique.
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Webinar
Using MDS to observe protein oligomerizationIn this webinar we explore protein oligomerization, and look at two case studies where microfluidic diffusional sizing (MDS) was used to observe changing oligomeric states.
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List
5 exciting papers on membrane proteinsThis list gives a summary and link to 5 excellent papers which highlight some of the most recent and exciting work taking place in the field of membrane proteins.
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Infographic
The cost of poor quality proteinThis infographic explores what is meant by "protein quality" - and where it can cause problems in research.
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Blog
Protein analysis techniques - a history and timelineProteins were discovered in the late 18th century, but analytical methods to observe them were not developed until more than 100 years later. This timeline shows when different techniques were developed.
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Infographic
The KD cheat sheetThis printable "cheat sheet" gives an overview of what KD, the dissociation constant, means, how to calculate it, and how to experimentally measure it.
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Publication
α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formationThis paper probes the interactions of α-synuclein with lipid particles using the Fluidity One and various other methods, to investigate the link between these interactions and α-synuclein aggregation.
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Blog
The importance of pre-crystallization screening of membrane proteins - and how to do itWe investigate the importance of pre-screening membrane proteins before crystallization, with examples and comments from the literature, and take a look at 4 methods which can be used to do this.