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Documentation
Fluidity One User ManualThe Fluidity One user manual with full safety and operation information.
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Blog
The role of analytics in the discovery and development of biopharmaceuticalsAs the biopharmaceuticals market continues to grow, how do laboratory analysis methods support discovery and development? And what should be considered when selecting an analysis method?
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Application note
Quantitation of low Tryptophan and Tyrosine peptides using the Fluidity OneUV absorbance is commonly used as a fast method for protein and peptide quantitation, however samples must contain tryptophan (Trp) or tyrosine (Tyr) residues to be detected. Here we demonstrate the ability of the Fluidity One to assess the concentration of a range of samples which have low or no Trp and Tyr content.
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Blog
Social Network. But For ProteinsAs the $31m investment round in Fluidic Analytics is announced, Vishal Gulati of Draper Esprit reflects on how he first met the founders, why proteins matter and how our technology is set to change protein science.
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Application note
Protein Size as an Indication of StructureMolecular weight (Mw) is a commonly used, and for many scientists a readily understood, parameter to describe the size of a protein or complex. Here we show how hydrodynamic radius (Rh) can be used in combination with Mw to provide insights into the shape and structure of proteins and illustrate how Mw alone may not always provide a complete picture.
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Documentation
Fluidity One reagent cartridge MSDS -
Documentation
Fluidity One Chip Flow factsheetThis factsheet shows how the microfluidic chips used with the Fluidity One work, through diagrams and a short description.
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Video
Introducing The Fluidity One - videoThis short video introduces the Fluidity One instrument, how it works, what Microfluidic Diffusional Sizing MDS is, and why native state protein analysis is so vital.
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Blog
Basel Life and Miptec 2018 - poster and presentation downloadThe Miptec exhibition at Basel Life 2018 marked the official launch of our Fluidity One instrument. Download a copy of our poster and presentation from the event here.
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Brochure
Fluidity One brochureThe Fluidity One brochure gives an overview of the capabilities, applications and full technical specifications.
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Application note
Oligomerization of Interleukin-2A commercially available human interleukin-2 is assessed by microfluidic diffusional sizing on the Fluidity One across a dilution series. The hydrodynamic radius is observed to increase with increasing concentration, in a way which suggests a monomer-trimer equilibrium with positive cooperativity is established.
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Application note
Interleukin-2 stability in changing buffer and temperature conditionsThe stability of interleukin-2 in different buffers and storage temperatures is evaluated using the Fluidity One. We find that IL-2 forms aggregates within 24 hours in some buffers, and that the Fluidity One provides a simple means to evaluate the stability of proteins across different conditions.
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Documentation
Removing primary amine containing additives from protein samples prior to testing on Fluidity OneA laboratory protocol for removing additives that contain primary amines before testing on the Fluidity One.
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Blog
What biophysical attributes of biopharmaceuticals are measured, and why?An array of characteristics must be investigated in new biopharmaceuticals to evaluate their safety, efficacy and behaviour under changing conditions. Here we look at what specific attributes should be measured and why.
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Blog
A day in the life of a Software Engineer at Fluidic AnalyticsPrincipal Software Engineer, Mauricio Varea, talks about his career path to date, working in large and small companies and what a typical day looks like for him at Fluidic Analytics.
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Blog
How does Microfluidic Diffusional Sizing (MDS) compare to Dynamic Light Scattering (DLS) for protein size tests?Measuring the size of proteins provides insights into folding and conformations, aggregation and oligomerization. We compare and contrast the benefits and limitations of two popular techniques - DLS Dynamic Light Scattering, and MDS Microfluidic Diffusional Sizing.
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Blog
A day in the life of a scientist at Fluidic AnalyticsAn interview with Dr Maren Butz, senior scientist at Fluidic Analytics. We find out what an average day looks like for her, how work in academia compares to industry, and how her work contributes to developing our instruments.
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Publication
Cooperative Assembly of Hsp70 Subdomain ClustersWright et al use Microfluidic Diffusional Sizing to probe the oligomerisation of the SBD641 substrate of human Hsp70. The Fluidity One was employed to verify if the fluorescent label used had an affect on measured hydrodynamic radius during the tests.
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Application note
A comparison of Microfluidic Diffusional Sizing with Dynamic Light Scattering and Taylor Dispersion AnalysisThe established technologies of Dynamic Light Scattering (DLS) and Taylor Dispersion Analysis (TDA) are compared to Microfluidic Diffusional Sizing (MDS) for sizing proteins of varying molecular weights and at varying concentrations. We show that MDS offers comparable sizing of proteins over a range of sizes, and can provide consistent sizing to lower concentrations than the other techniques.
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Blog
How does the Fluidity One compare to UV-Vis spectrophotometers in testing the concentration of proteins?UV-vis absorbance testing is a popular method for rapid testing of protein concentration with only a small sample volume needed. Here we compare this method to Microfluidic Diffusional Sizing (MDS), as used on the Fluidity One, to see how the workflow, accuracy, test method, range and limitations compare.