Protein Interactions Lab


Protein Interactions Lab

Services | Assay Development | Solutions

Experience first-hand how microfluidic diffusional sizing (MDS) adds power to your protein interaction toolbox.

Quantify and characterize any protein interaction –
even in complex backgrounds, even with challenging targets.

What if you could measure complex protein interactions in close to in vivo conditions?

What more could you discover?

From custom assay development and routine sample testing to outsourcing, our Protein Interactions Lab is designed to help you discover more.

Protein Interactions Lab – Services | Assay Development | Solutions

From custom assay development to outsourcing entire projects, let the Protein Interactions Lab be your partner.

Microfluidic Diffusional Sizing (MDS) is a proprietary technology which opens the door to quantify and characterize protein interactions, regardless of background or target complexity. Utilizing MDS technology, Fluidity One systems analyze the most challenging targets, in buffers, cell lysates or serum, to deliver molecular size, affinity (KD), concentration and stoichiometric data.


So far, the Protein Interactions Lab has helped researchers:

Characterize their
polyclonal antibodies

Follow functional immunity in infectious diseases, such as COVID-19

Reveal mechanisms of potential therapeutics in neurodegenerative disease

Differentiate between specific and
non-specific binding (aggregation)

Measure what really matters

See what you can discover when you put MDS at the heart of your protein interactions toolbox

The Protein Interactions Lab offers you instant access to the proprietary Fluidity One platform, developed and manufactured to our 9001 and 13485 certifications, so you can characterize and quantify protein interactions in solution.

Studying protein interactions with challenging samples in complex backgrounds?

MDS may have the answer. You won’t know until you try. Choose the Protein Interactions Lab as a go-to resource to accelerate progress – from custom protocol and assay development to routine sample testing.

Protein Labelling

Alexa Fluor™ 488 or 647 labelling, clean-up, determination of degree of labeling and QC

Protein Affinity Measurements

In-solution affinity measurements of purified proteins to other species* listed on our standard menu

MAAP Assays

Determination of serum antibody affinity
and concentration*

Affinity Based Neutralization Assays

Binary yes/no determination of neutralizing ability
of serum antibodies*

Custom Assay Development

Custom protocol & assay development as well as assay validation on custom samples

Data Analysis

Comprehensive report including data analysis and guidance on possible future directions

Accelerate progress with the Protein Interactions Lab

The comprehensive range of services include:

Outsourcing, custom protocol
and assay development

Develop custom protocols and assays together
with our experienced and dedicated scientists

Routine sample

Choose from a broad menu of assays for
routine sample testing

Protein labeling
and sourcing

Provide your own proteins or let us source
and label suitable proteins for you

Data analysis

Receive a comprehensive data report summarizing results and observations based on our analytical expertise with protein interactions

Comprehensive reporting

Benefit from our seamless end-to-end
project management LIMS

Which assays are on your standard menu?

Routine assays available

Protein labeling Labeling customer-provided protein with fluorophore (Alexa Fluor™ 488 or Alexa Fluor™ 647, clean-up, determination of degree of labeling, QC by Fluidity One-W). Proteins can be sourced directly on customer’s behalf at cost where third-party licence agreements permit. Note that this can be provided as a standalone service.

MAAP assay Determination of serum antibody affinity (to the targets listed on our standard assay menu) and concentration as per user guide (see SARS-CoV-2 Antibody Profiling User Guide for example).

Rapid affinity-based neutralization assay Binary yes/no determination of neutralizing ability of serum antibodies against the targets listed on our standard assay menu (see Affinity-based SARS-CoV-2 Surrogate Virus Neutralization Test for example).

KD of purified protein in buffer In-solution affinity measurement of purified protein binding to another species for proteins listed on our standard menu. For the above assays see our website for the full menu of validated targets we can offer. We are constantly expanding our menu so check back regularly.

What can the Protein Interactions Lab offer?

The fastest, most convenient way to access our transformational platform for quantifying protein interactions: You send us your samples. We send you a complete data set and in-depth analysis by one of our scientific experts.

Immediate access to our rapidly expanding menu of assays including:

  • Quantification of affinity and concentration in serum or other complex backgrounds
  • Molecular neutralization assays against mutant and wild-type SARS-CoV-2 antigens
  • Simple binding curves in purified samples

Bespoke assay development services to develop new versions of assays for your specific targets or completely new assays for your novel applications.

What if I need an assay that isn’t on your Standard Menu?

For cases where your application requires a bespoke assay, we can develop one for you. We will work together with you to establish the assay and validate it on samples of your choice.

What will I receive as a deliverable?

All service contracts come with a full report as the main deliverable. The report is in-depth and includes analysis of your data by one of our experts, including insights and possible future directions. You will also receive a copy of all raw data from your samples. Long-term sample storage after work is complete can be provided if required.

Will you keep a copy of my data?

Yes. An anonymized copy of all data will be kept in our system to help us improve our existing products and services and to develop new ones. We will not sell your data set or your personal data on to third parties.

Where will my samples be run?

Samples are routinely run in our CL2 service laboratory at Fluidic Analytics’ headquarters in Cambridge, UK. We also have a backup facility in Boston, Massachusetts, USA that can be called on when required.

What quality standards does Fluidic Analytics have in place?

Fluidic Analytics has been certified to ISO-9001 and ISO-13845.

Who will work on my samples?

All work will be led by our team of highly qualified staff with decades of experience working with biological samples. The scientists who will be working with you are all leading experts on Fluidic Analytics’ platform and its applications because they have helped to develop them since Day One.

(For research use only.)

Access the Protein Interactions Lab

Please just give us a few details about your work below and we'll be in touch to discuss the next steps in analyzing your protein interactions, even in complex backgrounds.

Could this support your research?

Get in touch, our applications scientists will be happy to discuss your application requirements with you.

Learn more