

Fluidity One-M
The only device that analyzes your most challenging interactions in complex backgrounds
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Why the Fluidity One-M?
Molecular size:
Robust interaction measurement with in-built quality control
Multi-attribute results:
Affinity (KD), concentration, stoichiometry, and size from a single experiment
In-solution:
Analyse disease-relevant proteins closer to their native environment and avoid non-specific surface binding, avidity, and misfolding
Purification-free:
Avoid sample purification and stability screening, even for membrane proteins
Maintenance-free design:
Containing fluidics within the consumable avoids clogging, priming, or flushing
Easy access:
Intuitive user interface provides guided experimental setup and automated data analysis
Key features
Sample volume per data point enables KD determination with as little as 50 µL of sample
Range for size measurement, covering peptides to multiprotein complexes and fibrillar aggregates
To generate 24 data points, providing a KD value in under an hour
Standalone benchtop instrument, operated by a touchscreen
Complex research in a simple workflow
Results in under 45 minutes with only 15 minutes hands-on time
Technology comparison
Technology comparison
Existing technologies
Immobilisation of proteins on a surface
- Non-specific binding
- Misfolding
- Avidity effects
Purification of proteins
- Non-native environments
- Time-consuming
Indirect measurement principle
- No in-built assay control
- Ambiguous results
- Expert know-how required
Flow-chip or capillary-based consumables
- Clogging with crude samples
- Cleaning and equilibration required
- Cross-contamination
- Cumbersome handling
Large sample volumes
- Lower number of replicates possible
- Less material available for complimentary measurements
Fluidity One-M
In-solution approach
- Direct use of disease-relevant proteins
- Native structure
- No avidity
Purification-free workflows
- Native environments possible
- Shorter time to result
Size-based measurement principle
- In-built assay control
- Highly reproducible and easy to interpret results
Plate-based consumables
- Works with serum, plasma, or lysates
- Fresh, ready-to-use consumable
- No cross-contamination
- Quick sample load with multi-channel pipettes
Small sample volumes
- More replicates
- More material available for orthogonal characterization
Case studies
Fluidity One-M specification
System
Interaction analysis
Consumables
Specifications
Dimensions
Find out more
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