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This webinar details new methods that have yielded new insights into the mechanisms of action of four clinical-stage anti-Abeta antibodies: aducanumab, gatenerumab, bapineuzumab and solanezumab. Kinetic analyses were combined with binding measurements performed using microfluidic diffusional sizing (MDS) to quantify the influence of these antibodies on the aggregation kinetics and on the production of oligomeric aggregates. It was demonstrated that these effects were linked to the affinity and stoichiometry of each antibody for monomeric and fibrillar forms of Abeta. These results reveal that, uniquely among these four antibodies, aducanumab dramatically reduces the flux of Abeta oligomers.
In this webinar, Prof. Linse discusses:
Sign up for an upcoming live webinar or view our archive of previous broadcasts, available to view on demand. All the latest webinars from Fluidic Analytics, covering a range of topics from mesauring antibody affinity in serum to Monitoring of SMALP nanodisc formation, to quantifying the stoichiometry and binding affinity of protein–protein interactions in complex backgrounds.
Understanding the nature of the immune response that leads to recovery from severe disease is key to developing effective treatments for COVID-19. In this webinar, Professor Akiko Iwasaki will discuss immune responses in COVID-19 patients with moderate and severe disease. She will compare viral load, immune phenotype and cytokines that are predictive of mortality, and discuss signatures of cytokines and growth factors that associate with recovery vs. disease exacerbation.
Prof. Adriano Aguzzi outlines the challenge in understanding the humoral immune response to COVID‑19, and therefore, predicting the degree of immune protection resulting from previous infection, vaccination and other treatments.
We present a new type of rapid assay that is based on quantifying these protein interactions and provides functional insights.
Detecting antibodies that confer effective immunity is crucially important in the fight against SARS-CoV-2.
Measuring antibody affinity in serum – it’s not as trivial as it sounds
We explore the differences between Affinity vs Avidity and hopefully dispel the vagueness you feel next time you come across them in a paper
MDS is an ideal tool to monitor SMALP nanodisc formation discover why in this webinar
Determination of binding affinity and stoichiometry of protein interactions without prior knowledge of the structure
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