Is my membrane protein in a micelle?
Membrane proteins represent approximately ¼ of the human proteome, and constitute over 50% of current drug targets. Well folded and functional protein for study however remains challenging, due to these problems associated with yield, solubility and stability. These in turn can make characterisation hard – with low concentrations and complex detergent based formulations preventing robust analysis.
Fluidic Analytics technology enables characterisation of this challenging class of proteins - solution state measurement coupled with high sensitivity and protein specific detection means you can optimize membrane protein purification conditions or assess protein-detergent complex formation without interference from detergents or empty micelles, and without a need to calibrate for each buffer type.