Membrane proteins represent approximately ¼ of the human proteome, and constitute over 50% of current drug targets. Obtaining well folded and functional protein for study however remains challenging, due to these problems associated with yield, solubulity and stability. These in turn can make characterisation hard – with low concentrations and complex detergent based formulations preventing robust analysis.
Fluidic Analytics technology enables characterisation of this challenging class of proteins - solution state measurement coupled with high sensitivity and protein specific detection on the Fluidity One means you can optimize membrane protein purification conditions or assess protein-detergent complex formation without interference from detergents or empty micelles, and without a need to calibrate for each buffer type.