Application noteA comparison of Microfluidic Diffusional Sizing with Dynamic Light Scattering and Taylor Dispersion Analysis
The established technologies of Dynamic Light Scattering (DLS) and Taylor Dispersion Analysis (TDA) are compared to Microfluidic Diffusional Sizing (MDS) for sizing proteins of varying molecular weights and at varying concentrations. We show that MDS offers comparable sizing of proteins over a range of sizes, and can provide consistent sizing to lower concentrations than the other techniques.
Application noteDetecting insulin oligomerisation using microfluidic diffusional sizing
Insulin monomers self-assemble into hexamers, which is known to affect its level of uptake in the human body. Here we show that Microfluidic Diffusional Sizing (MDS) can be used to detect these changes.
Application noteComparison of microfluidic diffusional sizing and ThT spectroscopy for the assessment of α-synuclein amyloid fibril growth
The aggregation of α-Synuclein results in insoluble amyloid fibrils. Here we show that Microfluidic Diffusional Sizing (MDS) offers a new approach to study these aggregations in their native state.